Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing
Michael A. Raddatz, Tessa M. Huffstater, Matthew R. Bersi, Bradley I. Reinfeld, Matthew Z. Madden, Sabrina E. Booton, W. Kimryn Rathmell, Jeffrey C. Rathmell, Brian R. Lindman, Meena S. Madhur, W. David Merryman
This study shows that macrophages in Notch1+/- mice promote osteogenic calcification in aortic valves through STAT3 splicing changes and increased recruitment and polarization.
Arteriosclerosis Thrombosis and Vascular Biology · Apr 16, 2020Peer-reviewedMolecular Biology