Matthew Z. Madden

This study identifies HELZ as an RNA-DNA helicase that resolves R loops to support homologous recombination repair and genomic stability.

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

This study shows FABP5 regulates ether lipid metabolism, reducing inflammation in atopic dermatitis by modulating platelet activating factor levels.

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

This study shows that macrophages in Notch1+/- mice promote osteogenic calcification in aortic valves through STAT3 splicing changes and increased recruitment and polarization.