FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway
Kayque Alves Telles-Silva, Lara Varela Bastos Pacheco, Sabrina Komatsu, Fernanda Chianca, Gustavo Chagas, Gabrielly Cristine Martins, Maria M. Gridina, Daria Panchenko, Valdemir Melechco Carvalho, Elia Tamaso Espin Garcia Caldini, Veniamin Fishman, Michelle R. Arkin, Ernesto Goulart, Mayana Zatz
This study shows that FOXM1 inhibition promotes terminal differentiation of human iPSC-derived hepatocytes by enhancing polyploidization and metabolic maturation through the Wnt/β-catenin pathway.
bioRxiv · Jun 17, 2025 · PreprintCell Biology