Maria M. Gridina

CTCF gradually acquires novel function modalities during bilaterian evolution

This study investigates how CTCF's functional properties evolved across bilaterian species, revealing gradual changes in its ability to regulate chromatin structure and transcription.

The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization

This paper integrates single-cell Hi-C, RNA-seq, and microscopy to uncover how hypertranscription shapes lampbrush chromosome structure through transcription-dependent chromatin organization.

Zooming into rearranged genome: applying pipeline of cytological, genomic, and transcriptomic methods for structural variant interpretation

The paper demonstrates an integrative approach combining cytological, genomic, and transcriptomic methods to detect and characterize complex structural variants affecting specific genes and report a new neurodevelopmental phenotype.

Condensins-mediated mitotic folding persists as a structural echo in interphase chromatin

The paper investigates how condensins shape chromatin contacts in interphase nuclei using Hi-C data from mouse embryonic stem cells, showing structural memory of mitotic folding.

FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway

This study shows that FOXM1 inhibition promotes terminal differentiation of human iPSC-derived hepatocytes by enhancing polyploidization and metabolic maturation through the Wnt/β-catenin pathway.

A novel approach for simultaneous detection of structural and single-nucleotide variants based on a combination of chromosome conformation capture and exome sequencing

This paper introduces a method combining exome sequencing and chromosome conformation capture to detect both SNVs and SVs, demonstrating its effectiveness in identifying causative variants in rare disorders.

Expanding the list of sequence-agnostic enzymes for chromatin conformation capture assays with S1 nuclease

This paper introduces an S1 nuclease-based Hi-C method for chromatin conformation capture, offering improved chromatin fragmentation and library preparation compared to DNase I Hi-C.

Comparison and critical assessment of single-cell Hi-C protocols

This study compares two single-cell Hi-C protocols, showing that whole-genome amplification introduces more artifacts and noise than PCR-based amplification.