Michelle R. Arkin

Fluorescence polarization-based fragment screen identifies inhibitors of APOBEC3A and APOBEC3B

This study identifies small molecule inhibitors of APOBEC3A and APOBEC3B using a fluorescence polarization assay, revealing compounds that disrupt DNA interactions and deaminase activity.

Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening

This study identifies non-nucleoside inhibitors of EV-D68 3D polymerase through crystallographic fragment and high-throughput screening, revealing potential drug targets and lead compounds.

Modulation of the 14-3-3σ/C-RAF autoinhibited complexby molecular glues

This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.

FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway

This study shows that FOXM1 inhibition promotes terminal differentiation of human iPSC-derived hepatocytes by enhancing polyploidization and metabolic maturation through the Wnt/β-catenin pathway.

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus-MPro inhibitors with potent in vivo efficacy

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

The paper trains a deep metric learning model on zebrafish behavioral profiles to identify neuroactive compounds, achieving better performance than correlation distance and validating predictions with in vitro assays.

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1/GAT-1 variants

The paper investigates the functional consequences of SLC6A1 variants, finding haploinsufficiency underlies neurodevelopmental phenotypes and identifying missense residues sensitive to substitution.

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation

This study shows that caspase inhibition reduces tau cleavage and neurotoxicity in iPSC-derived neurons with the V337M MAPT mutation.

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend C. elegans Lifespan

The paper screens 100,000 small molecules in human fibroblasts to find those increasing oxidative stress resistance and extending C. elegans lifespan.