Profound synthetic lethality between SMARCAL1 and FANCM
Sumin Feng, Kaiwen Liu, Jinfeng Shang, Lisa Hoeg, Graziana Pastore, William E. Yang, Sabrina Roy, Guillermo Sastre-Moreno, Jordan T.F. Young, Wei Wu, Dongyi Xu, Daniel Durocher
The paper identifies a synthetic lethal relationship between SMARCAL1 and FANCM, showing their combined loss causes severe genome instability due to chromosome breakage at simple repeat regions.
Molecular Cell · Nov 6, 2024Peer-reviewedMolecular Biology