Dongyi Xu

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

The paper identifies a synthetic lethal relationship between SMARCAL1 and FANCM, showing their combined loss causes severe genome instability due to chromosome breakage at simple repeat regions.

This study identifies ASF1 as a partner of RIF1 that promotes NHEJ by compacting chromatin and suppressing resection in BRCA1-deficient cells.