Lisa Hoeg

This study identifies SLC25A28 as a synthetic lethal target in NER-deficient cancers, showing its loss impairs cell viability and increases oxidative stress.

The paper identifies DDIAS as a DNA-binding effector of the CIP2A-TOPBP1 complex that suppresses single-stranded DNA during mitosis, protecting genome integrity and interacting genetically with DNA polymerase.

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

The paper identifies a synthetic lethal relationship between SMARCAL1 and FANCM, showing their combined loss causes severe genome instability due to chromosome breakage at simple repeat regions.

This study shows that loss of Nkd1 is epistatic to loss of Axin2 in Wnt signaling regulation in zebrafish, with double mutants resembling Nkd1 single mutants.

The paper identifies NFATC2IP as a mediator of SUMO-dependent genome integrity through CRISPR/Cas9 screens and functional validation.

The paper uses AlphaFold2 to predict structural interactions in the 53BP1 pathway, identifying a novel RIF1-SHLD3 binding interface critical for DNA repair.

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.