Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function
Gabriel B. Loeb, Pooja Kathail, Richard W. Shuai, Ryan Chung, Reinier J. Grona, Sailaja Peddada, Volkan Sevi̇m, Scot Federman, Karl Mader, Audrey Y. Chu, Jonathan Davitte, Juan Du, Alexander R. Gupta, Chun Ye, Shawn Shafer, , Jeremy F. Reiter
This paper identifies genetic variants in tubule epithelial regulatory elements that explain most heritable differences in human kidney function using GWAS, scATAC-seq, and functional assays.
Nature Genetics · Sep 10, 2024Peer-reviewedGenetics