Jeremy F. Reiter

Primary cilia promote cardiac fibrosis and limit heart function after myocardial infarction

This study shows that primary cilia in cardiac fibroblasts promote fibrosis and impair heart function after myocardial infarction by amplifying fibrotic signaling.

Primary cilia and BBS4 are required for postnatal pituitary development

The paper shows that cilia and BBS4 are essential for postnatal pituitary development through Hedgehog signaling.

A stem cell-based platform for functional analysis of genetic variants in lung disease

This study develops an iPSC-based platform to functionally analyze genetic variants in lung disease, demonstrating its application in diagnosing a variant of uncertain significance in primary ciliary dyskinesia.

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture

This study identifies RSG1/CPLANE2 as a causative gene for human ciliopathy and shows its role in ciliary transition zone assembly.

Smoothened inhibition of PKA at cilia transduces Hedgehog signals

The paper shows that SMO inhibits PKA at cilia to activate the HH signaling pathway, dependent on GRK2/3.

Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function

This paper identifies genetic variants in tubule epithelial regulatory elements that explain most heritable differences in human kidney function using GWAS, scATAC-seq, and functional assays.

Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain

The paper investigates how physiological conditions like feeding, obesity, and circadian rhythm affect ciliary GPCR localization and cilia dynamics in the brain using MCHR1 and NPY2R as models.

Opposing transcription factors MYCL and HEY1 mediate the Notch-dependent airway stem cell fate decision

The paper identifies MYCL and HEY1 as opposing transcription factors mediating Notch-dependent airway stem cell fate decisions through single-cell RNA sequencing and CUT&RUN.

ATXN10 is required for embryonic heart development and maintenance of epithelial cell phenotypes in the adult kidney and pancreas

This study shows that Atxn10 is essential for embryonic heart development and adult kidney and pancreas function, with loss leading to lethality and epithelial to mesenchymal transition.

Ciliary Hedgehog signaling regulates cell survival to build the facial midline

The paper shows that ciliary Hedgehog signaling is essential for cell survival in the facial midline, and its disruption causes craniofacial defects in mouse models of ciliopathies.

The single pass membrane protein MRAP2 regulates energy homeostasis by promoting primary cilia localization of the G protein-coupled receptor MC4R

This study shows that MRAP2 is essential for MC4R's localization to primary cilia and its role in regulating energy homeostasis and body weight.

Ciliary signaling-patterned smooth muscle drives tubular elongation

This study shows that ciliary signaling patterns smooth muscle, which generates mechanical forces that activate YAP to drive longitudinal growth in the developing esophagus and small intestine.

DYRK2 is a ciliary kinase involved 1 in vertebrate Hedgehog signal transduction

This paper identifies DYRK2 as a ciliary kinase involved in Hedgehog signal transduction, showing its role in ciliary morphology and skeletal development.

A transient role of primary cilia in controlling direct versus indirect neurogenesis in the developing cerebral cortex

This study shows that primary cilia regulate direct versus indirect neurogenesis in the developing cerebral cortex, with Inpp5e mutations causing increased direct neurogenesis and layer V neuron overproduction.