Scot Federman

The paper introduces CAT-ATAC, a method combining CRISPR, RNA, and ATAC-seq in single cells to identify gene regulatory relationships and validate them with loss-of-function experiments.

The paper develops a SAMHD1 knockout iPSC model that enhances lentiviral transduction efficiency in myeloid cells, enabling better functional genomics studies in innate immunity and inflammatory diseases.

This paper identifies genetic variants in tubule epithelial regulatory elements that explain most heritable differences in human kidney function using GWAS, scATAC-seq, and functional assays.

This paper optimizes CRISPR guide RNA library cloning to reduce bias and enables more compact genetic screens with equivalent results using fewer cells.

This study uses rapid diagnostics and metatranscriptomics to analyze SARS-CoV-2 infection, revealing viral evolution, host responses, and drug interactions in NYC samples.

The paper validates a clinical metagenomic sequencing assay for detecting pathogens in cerebrospinal fluid, showing 73% sensitivity and 99% specificity compared to clinical tests.

This study evaluates nanopore sequencing performance on the ISS, showing no performance decrease and successful genome assembly of bacterial and mammalian samples.

The paper reports the first draft genome assembly of Balamuthia mandrillaris from a PAM survivor and highlights the need for reference genomes in metagenomic diagnosis.

This study uses real-time nanopore sequencing and a new pipeline to rapidly detect viral pathogens in clinical samples with high accuracy.