The Amt2 Gene is Key for Cryptococcus neoformans Transmigration Across The Blood-Brain Barrier and Closely Linked to Its Capsule Formation
Sainamthip Rangdist, Ekkasit Kanklang, Natchaya Pakdeesiriwong, Watsana Penkhrue, Chompunoot Wangboon, Oratai Weeranantanapan, Sirilak Chumkiew, Pathanin Chantree, Pongsakorn Martviset, Methee Chayakulkeeree, Mantana Jamklang
This study identifies the Amt2 gene's role in Cryptococcus neoformans transmigration across the blood-brain barrier and its link to capsule formation, without affecting endothelial cell damage.
bioRxiv · Jan 30, 2026 · PreprintMicrobiology