Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
Xing Yuan Guo, Cong Liu, Yuhong Wang, Hongxin Li, Saiwen Ma, Na Lei, Huiling Ren, Yuezhi Lin, Xiaojun Wang
This study identifies how EIAV vaccine Env regulates NLRP3 inflammasome activation by reducing NLRP3-NEK7 complex formation while preserving P2X7-mediated ion flux.
PLoS Pathogens · Jun 16, 2025Peer-reviewedImmunology