Elevated cortical tension triggers precocious ectopic polarization in mammalian oocytes, associated with lower developmental potential.
Anastasia Shihabi, Eric Neiva, Gaëlle Letort, Elvira Nikalayevich, Sajjad Madhavi, Mohamed Yahiatene, Xavier Pollet‐Villard, Herve Turlier, Marie‐Hélène Verlhac, Marie‐Emilie Terret
The paper shows that elevated cortical tension in mammalian oocytes causes early ectopic polarization, leading to developmental issues.
bioRxiv · Oct 19, 2026 · PreprintCell Biology