Gaëlle Letort

The paper shows that elevated cortical tension in mammalian oocytes causes early ectopic polarization, leading to developmental issues.

The paper identifies a novel RNP compartment in mouse oocytes that enhances translation to counteract cytoplasmic dilution during growth.

EpiCure is a tool for curating epithelial segmentation errors in 2D movies, improving accuracy and efficiency in single-cell dynamics analysis.

This study links transcriptomic data with real-time cell behavior to uncover molecular fate asymmetry and a quiescence cycle in adult neural stem cells.

This study shows that glial cell adhesion molecules regulate neural stem cell proliferation by modulating mechanical forces and nuclear integrity in Drosophila.

This study shows mTORC1 supports quiescent NSCs in acquiring activation competence, challenging its role as solely a proliferation regulator.

FishFeats provides a streamlined pipeline for quantifying multimodal labeling in 3D tissues, integrating image analysis steps into a user-friendly tool for non-computational users.

This study uses live imaging to show that Duchenne Muscular Dystrophy mouse model MuSCs have impaired migration and premature differentiation due to altered signaling pathways, with intrinsic and extracellular factors influencing their behavior.

This study identifies novel epithelial roles of VANGL2 in shaping the mouse heart tube through cell rearrangements and midline symmetry control, independent of planar polarity.

The paper shows that local activation of Cxcl12a signaling during zebrafish olfactory placode morphogenesis is critical for proper development, with spatial and temporal control influencing the process.

This paper develops a microfluidic device to non-invasively measure mouse oocyte deformability, identifying elasticity as a key factor in mechanical health and potential for improved assisted reproduction.

The paper identifies distinct molecular and functional properties of extraocular muscle stem cells compared to limb muscle stem cells using scRNA-seq and other methods.

DeXtrusion automatically detects cell extrusion and death in epithelial tissues using machine learning, improving efficiency over manual methods.

This paper develops a machine learning framework for oocyte phenotyping using transmitted light images, identifying new features to assess maturation potential in mouse and human oocytes.

The paper compares molecular and functional maturation of brain vascular cells in mice and humans during postnatal development, identifying key markers and processes in endothelial and vascular smooth muscle cells.

PhysiBoSS integrates multi-scale agent-based modelling with Boolean networks to study cell population dynamics and treatment responses in 2D and 3D environments.