Longitudinal tracking reveals sustained polyclonal repopulation of human-HSPC in humanized mice despite vector integration bias
Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim, Wannisa Khamaikawin, Samantha Lin, Saki Shimizu, Koollawat Chupradit, Yoojin Lee, Yiming Xie, Xin Guan, Vasantika Suryawanshi, Angela P. Presson, Dong Sung An, Irvin S. Y. Chen
This study tracks clonal repopulation of human HSPC in humanized mice and finds polyclonal repopulation stabilizes rapidly with no negative effects from vector integration bias.
bioRxiv · Aug 21, 2020 · PreprintMolecular Biology