Author

Irvin S. Y. Chen

University of California, Los AngelesORCID 0000-0003-1199-2415Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:rat· 2 Assay:ATAC-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Sanggu KimiD· 3 shared Tom ChouiD· 2 shared Angela P. PressoniD· 1 shared Dong Sung AniD· 1 shared Gajendra W. SuryawanshiiD· 1 shared Hubert ArokiumiD· 1 shared Koollawat Chupradit· 1 shared Saki Shimizu· 1 shared

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2015-2020 · peak 1/yr

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10 top collaborators · 31 mutual co-author links

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3 shared papersSystems Biology

Sanggu KimORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 21, 2020

Longitudinal tracking reveals sustained polyclonal repopulation of human-HSPC in humanized mice despite vector integration bias

Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim…·Irvin S. Y. Chen

This study tracks clonal repopulation of human HSPC in humanized mice and finds polyclonal repopulation stabilizes rapidly with no negative effects from vector integration bias.

DOI 10.1101/2020.08.21.261537

humanATAC-seq

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Systems BiologyPLoS Computational BiologyPeer-reviewedOct 18, 2018

Modeling large fluctuations of thousands of clones during hematopoiesis: the role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque

Song Xu, Sanggu Kim, Irvin S. Y. Chen, Tom Chou

The paper models clone fluctuations in rhesus macaque hematopoiesis, showing that stochastic HSC self-renewal and progenitor proliferation constraints explain large temporal variations in clone abundance.

17 citations

ratbulk RNA-seq

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Systems BiologyBMC BiologyPeer-reviewedOct 20, 2015

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaque

Sidhartha Goyal, Sanggu Kim, Irvin S. Y. Chen, Tom Chou

The paper tracks clonal lineages in rhesus macaques to model blood cell population dynamics and identifies parameters governing clone size distribution.

DOI 10.1186/s12915-015-0191-8

ratstatistical model

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