Dong Sung An

This paper develops an HSPC-based gene therapy with anti-HIV-1 genes and a safety kill switch, showing significant viral load reduction in huBLT mice.

This paper develops a temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery, achieving high gene editing efficiency in human cells without triggering immune responses.

This study tracks clonal repopulation of human HSPC in humanized mice and finds polyclonal repopulation stabilizes rapidly with no negative effects from vector integration bias.