Xin Guan

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

Long-range transport of biomolecular condensates by Marangoni effect

The paper identifies the Marangoni effect as a mechanism for intracellular transport of biomolecular condensates using C. elegans zygotes and in vitro experiments.

NAADP elicits two-pore channel currents by lifting Lsm12-mediated inhibition of PI(3,5)P2 activation

This study shows NAADP reverses Lsm12 inhibition of PI(3,5)P2-dependent TPC activation, enabling Ca2+ release from acidic organelles.

LRRC55 modulates BK channels to support Purkinje cell plasticity and motor coordination

This study identifies LRRC55 as an auxiliary subunit of BK channels in Purkinje cells, showing its role in motor coordination and synaptic plasticity through BK channel modulation.

TCRAD: An End-to-End Framework for Antigen-Targeted T Cell Receptor Design

TCRAD designs antigen-specific TCR CDR3β sequences using deep learning, achieving high accuracy in binder discrimination and structure prediction, with experimental validation showing 17.2% functional candidates.

A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain

This paper introduces a wearable spiral ultrasound patch for non-invasive treatment of diabetic neuropathic pain, showing significant pain relief and improved nerve conduction in a rat model.

Longitudinal tracking reveals sustained polyclonal repopulation of human-HSPC in humanized mice despite vector integration bias

This study tracks clonal repopulation of human HSPC in humanized mice and finds polyclonal repopulation stabilizes rapidly with no negative effects from vector integration bias.

Numerous new mitogenomic sequences and multiple new environmental DNA markers for invasive bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) populations in North America

This study develops new species-specific genetic markers for detecting invasive bighead and silver carp in North American waterways using eDNA, showing improved performance and efficiency.