Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors
Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Sayantan Saha, Hiroaki Akasaka, Takaaki Kobayashi, Nashrah Zaidi, Sudha Mishra, Annu Dalal, Samanwita Mohapatra, Manish K. Yadav, Yuzuru Itoh, Rob Leurs, Andy Chevigné, , Arun K. Shukla
This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.
bioRxiv · Feb 1, 2024 · PreprintBiochemistry