Modular PEGylation Confers Reduced Immune-Cell Uptake and Enhanced Pharmacokinetic Performance to Encapsulin Protein Nanocages
Yi Wen Ng, Claire Rennie, India Boyton, Henrico Adrian, Saluo Lai, Daryl Ariawan, Peter Richard Wich, Ole Tietz, Andrew Care
This study shows that modular PEGylation of encapsulin nanocages reduces macrophage uptake and extends circulation time in mice.
bioRxiv · Sep 17, 2026 · PreprintBioengineering