INVA8001, a Novel and Highly Selective Chymase Inhibitor, Ameliorates Liver Inflammation, Fibrosis, and Hyperplasia in Mdr2 Knockout Mice
Sameer Sharma, Lixian Chen, Tianhao Zhou, Meenakshi Chawla, Anita Ganjoo, Shunichiro Okada, Salvatore Alesci, Krishnan Nandabalan, Heather Francis
This study evaluates the efficacy of INVA8001, a chymase inhibitor, in reducing liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice with PSC-like features.
Frontiers in Medicine · Jun 9, 2026Peer-reviewedPathology