PathologyFrontiers in MedicinePeer-reviewed
INVA8001, a Novel and Highly Selective Chymase Inhibitor, Ameliorates Liver Inflammation, Fibrosis, and Hyperplasia in Mdr2 Knockout Mice
Sameer Sharma, Lixian Chen, Tianhao Zhou…·Heather Francis
This study evaluates the efficacy of INVA8001, a chymase inhibitor, in reducing liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice with PSC-like features.
DOI 10.3389/fmed.2026.1840071