Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling
Tong Gao, Nicholas A. Maskalenko, Salvin Kabir, Kerry S. Campbell, Jinhua Wu
This study determines the crystal structure of talin head bound to β2-integrin tail, revealing species-specific mechanisms of integrin activation through a two-mode binding configuration.
Cell Reports · Apr 29, 2025Peer-reviewedBiochemistry