Author

Tong Gao

Fox Chase Cancer CenterORCID 0000-0002-6879-7680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Jinhua WuiD· 3 shared Alison KurimchakiD· 1 shared Bojana GligorijeviciD· 1 shared Elizaveta BelovaiD· 1 shared Heinrich RöderiD· 1 shared James S. DuncaniD· 1 shared Kathrine Wang· 1 shared Kerry S. CampbelliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

Jinhua WuORCID

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3 papers

Recent·Most cited

Engineering Stapled Peptide Inhibitors Reveals Design Principles for Targeting Talin-Induced Integrin Activation

Tong Gao, Elizaveta Belova, Yujiro MORI, Kathrine Wang, William H. Deni, Heinrich Röder, Bojana Gligorijevic, Jinhua Wu

The paper designs stapled peptides targeting talin-induced integrin activation, showing improved binding and cell uptake in optimized versions.

bioRxiv · Aug 31, 2026 · PreprintBiochemistry

Rac1 Selectively Binds a Specific Lamellipodin Isoform via a Noncanonical Helical Interface

Tong Gao, Pingfeng Zhang, Alison Kurimchak, James S. Duncan, Jinhua Wu

The paper shows that the short Lpd isoform specifically binds Rac1 via a noncanonical helical interface, revealing a novel isoform-dependent GTPase-effector interaction.

Journal of Biological Chemistry · Dec 6, 2025Peer-reviewedBiochemistry

Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling

Tong Gao, Nicholas A. Maskalenko, Salvin Kabir, Kerry S. Campbell, Jinhua Wu

This study determines the crystal structure of talin head bound to β2-integrin tail, revealing species-specific mechanisms of integrin activation through a two-mode binding configuration.

Cell Reports · Apr 29, 2025Peer-reviewedBiochemistry