Author

Nicholas A. Maskalenko

Fox Chase Cancer CenterORCID 0000-0001-7690-5234Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

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Jinhua WuiD· 1 shared Kerry S. CampbelliD· 1 shared Salvin Kabir· 1 shared Tong GaoiD· 1 shared

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2025-2025 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Jinhua WuORCID

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1 paper

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BiochemistryCell ReportsPeer-reviewedApr 29, 2025

Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling

Tong Gao, Nicholas A. Maskalenko, Salvin Kabir…·Jinhua Wu

This study determines the crystal structure of talin head bound to β2-integrin tail, revealing species-specific mechanisms of integrin activation through a two-mode binding configuration.

7 citationstop 5%

humanstructural biology

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