Covalent Modulators of Immune Regulatory Transcription Factors IRF8 and IRF5
Thang Do Cong, Henry Chan, Justin Greene, Sam Sabaat, Connor Ludwig, Nathan S. Abell, Matthew L. Albert, Sriram Kosuri, Daniel K. Nomura
This paper identifies covalent modulators that target and degrade IRF5 and IRF8, key inflammatory transcription factors, with TH-B10 showing potent and selective degradation of IRF8.
bioRxiv · Aug 3, 2025 · PreprintBiochemistry