Connor Ludwig

A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction

The paper presents a high-resolution map of RHO missense variants' trafficking and evaluates pharmacologic correction with YC-001, identifying pathogenic variants and therapeutic potential.

Covalent Modulators of Immune Regulatory Transcription Factors IRF8 and IRF5

This paper identifies covalent modulators that target and degrade IRF5 and IRF8, key inflammatory transcription factors, with TH-B10 showing potent and selective degradation of IRF8.

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

The paper develops HT-recruit to measure transcriptional effector function across contexts and identifies context-dependent effectors for CRISPR-based transcription control.

High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

The paper develops a method to generate functional nanobodies for gene regulation and epigenetic control in human cells, identifying tens of effective nanobodies.

High-throughput functional characterization of combinations of transcriptional activators and repressors

The paper measures how combinations of transcriptional activators and repressors affect gene expression and uses this to create a tunable synthetic transcription factor.

High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells

The paper identifies and characterizes viral transcriptional effector domains from coronaviruses and herpesviruses using high-throughput assays and perturbations.

Large-scale mapping and systematic mutagenesis of human transcriptional effector domains

The paper systematically maps and characterizes transcriptional effector domains in human chromatin regulators and transcription factors, identifying new activation and repression domains and their functional features.

Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

The paper studies how gene silencing and reactivation spread between neighboring genes in single cells, finding different dynamics based on chromatin regulators and insulator elements.