The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern
Saman Amini, Annika Jacobsen, Olga Ivanova, Philip Lijnzaad, Jaap Heringa, Frank C. P. Holstege, K. Anton Feenstra, Patrick Kemmeren
The paper compares genetic interaction patterns between gene-specific transcription factors and signaling genes in yeast, finding inversion is more common in transcription factors due to differential regulation.
PLoS Computational Biology · May 13, 2019Peer-reviewedGenetics