Cell BiologybioRxivPreprint
Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation
Samuel J. Reisman, Dahlia Halabi, Samantha E. Miller…·Charles A. Gersbach
The paper identifies transcription factors for reprogramming human astrocytes to neurons using CRISPRa screens and scRNA-seq, showing INSM1's broad neurogenic activity and cofactor interactions.