Author

Dahlia Halabi

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Charles A. GersbachiD· 2 shared Gregory E. CrawfordiD· 2 shared Nicholas Sangvai· 2 shared Samuel J. Reisman· 2 shared Alexias SafiiD· 1 shared Grayson RiceiD· 1 shared Lingyun SongiD· 1 shared Raluca GordâniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Charles A. GersbachORCID

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2 papers

Recent·Most cited

Mismatch tolerance of a gRNA for CRISPR-based gene activation confers broad activity critical for cell reprogramming

Samuel J. Reisman, Wei Zhu, Samantha E Miller, Dahlia Halabi, Nicholas Sangvai, Gregory E. Crawford, Raluca Gordân, Charles A. Gersbach

The paper identifies a CRISPRa gRNA with broad off-target activity that enables genome-wide transcriptional reprogramming, showing that mismatch tolerance and PAM-proximal bases determine binding specificity.

bioRxiv · Feb 3, 2026 · PreprintGenomics

Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation

Samuel J. Reisman, Dahlia Halabi, Samantha E. Miller, Lingyun Song, Sara Geraghty, Nicholas Sangvai, Grayson Rice, Alexias Safi, Gregory E. Crawford, Charles A. Gersbach

The paper identifies transcription factors for reprogramming human astrocytes to neurons using CRISPRa screens and scRNA-seq, showing INSM1's broad neurogenic activity and cofactor interactions.

bioRxiv · Oct 11, 2025 · PreprintCell Biology