Author

Samuel J. Reisman

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Charles A. GersbachiD· 4 shared Gregory E. CrawfordiD· 4 shared Alexias SafiiD· 3 shared Dahlia Halabi· 2 shared Lingyun SongiD· 2 shared Nicholas Sangvai· 2 shared Raluca GordâniD· 2 shared Samantha E Miller· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersGenomics

Charles A. GersbachORCID

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4 papers

Recent·Most cited

Quantitative profiling of intrinsic dCas9-DNA recognition reveals key determinants of guide RNA performance

Wei Zhu, Michael Tian, Yuncheng Duan, Samuel J. Reisman, Samantha E Miller, Evan Corden, Maria A. ter Weele, Lingyun Song, Jameson Blount, Alexias Safi, Jacob Matthew Schreiber, Charles A. Gersbach, Gregory E. Crawford, Raluca Gordân

This study quantifies intrinsic dCas9-DNA recognition using TANGO, identifying key factors affecting gRNA performance and revealing new aspects of dCas9 specificity.

bioRxiv · Aug 10, 2026 · PreprintGenomics

Reprogramming of neuronal genome function and phenotype by astrocytes

Boxun Li, Kevin T. Hagy, Alexias Safi, M Beer, Alejandro Barrera, Sara Geraghty, Ruhi Rai, Alyssa N. Pederson, Samuel J. Reisman, Michael I Love, Patrick F. Sullivan, Çağla Eroğlu, Gregory E. Crawford, Charles A. Gersbach

This paper shows that astrocytes reprogram neuronal gene expression and chromatin accessibility, affecting thousands of genes and regulatory elements, including those linked to schizophrenia and Alzheimer's disease.

bioRxiv · Mar 7, 2026 · PreprintGenomics

Mismatch tolerance of a gRNA for CRISPR-based gene activation confers broad activity critical for cell reprogramming

Samuel J. Reisman, Wei Zhu, Samantha E Miller, Dahlia Halabi, Nicholas Sangvai, Gregory E. Crawford, Raluca Gordân, Charles A. Gersbach

The paper identifies a CRISPRa gRNA with broad off-target activity that enables genome-wide transcriptional reprogramming, showing that mismatch tolerance and PAM-proximal bases determine binding specificity.

bioRxiv · Feb 3, 2026 · PreprintGenomics

Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation

Samuel J. Reisman, Dahlia Halabi, Samantha E. Miller, Lingyun Song, Sara Geraghty, Nicholas Sangvai, Grayson Rice, Alexias Safi, Gregory E. Crawford, Charles A. Gersbach

The paper identifies transcription factors for reprogramming human astrocytes to neurons using CRISPRa screens and scRNA-seq, showing INSM1's broad neurogenic activity and cofactor interactions.

bioRxiv · Oct 11, 2025 · PreprintCell Biology