Delayed protective effect of chronic variable stress on optic tract axonal degeneration after experimental TBI
Macy Urig, Jordyn N. Torrens, Shelby M. Hetzer, Emma G. Burke, John M. Riccobono, Abby Atreya, Samantha Lingo, James P. Herman, Nathan K. Evanson
This study shows that chronic variable stress after TBI initially worsens axonal degeneration but later provides a delayed protective effect, possibly through changes in microglial and astrocytic phagocytic activity.
bioRxiv · Oct 2, 2025 · PreprintNeuroscience