James P. Herman

This study investigates the long-term behavioral and molecular effects of adolescent chronic variable stress in rats, revealing sex- and region-specific changes in corticolimbic circuits.

This study identifies a neural circuit involving the subfornical organ and infralimbic cortex that modulates fear responses to carbon dioxide, linking interoceptive signals to fear behavior.

This study shows that chronic variable stress after TBI initially worsens axonal degeneration but later provides a delayed protective effect, possibly through changes in microglial and astrocytic phagocytic activity.

This study investigates sex-specific effects of PACAP in a PTSD model, finding differential behavioral outcomes in male and female rats following stress.

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

The paper uses sn-RNAseq data to identify cell-type-specific vulnerabilities to diseases and drugs in the anterior cingulate cortex, revealing distinct patterns of disease-state and drug effects.

This study shows that adolescent stress can reduce the negative effects of traumatic stress in adulthood, with sex-specific changes in brain regions involved in fear responses.

This study compares psychiatric disorders using pathway, cell-type, drug-target, and chromosomal analyses to identify common and distinct features across an unbiased cluster of disorders.

This study shows that reducing glutamate output in the infralimbic cortex of rats alters neural activity and behavior after chronic stress, highlighting its role in stress-related disorders.

This study inhibits prefrontal cortex parvalbumin interneurons in mice using DREADDs and shows that it reduces chronic stress-related behaviors and physiological changes.

This study shows that reducing glutamate release from infralimbic cortex neurons increases cardiovascular reactivity and vascular dysfunction under chronic stress.

This study examines how adolescent chronic stress affects behavior and physiology differently in male and female rats, with GR signaling playing a role in some outcomes.

This study uses CRISPR/Cas9 to create a conditional GR knockout in rats, showing sex-specific behavioral effects of GR deletion in the prelimbic cortex.