Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2
Jia He, Adriana Blazeski, Uthayanan Nilanthi, Javier Menéndez, Samuel C. Pirani, Daniel S. Levic, Michel Bagnat, Manvendra Kumar Singh, José G. Raya, Guillermo García‐Cardeña, Jesús Torres‐Vázquez
The paper identifies Plexin-D1 as a mechanosensor that regulates Dorsal Aorta caliber through KLF2-mediated endothelial cell enlargement.
bioRxiv · Jan 24, 2024 · PreprintDevelopmental Biology