Michel Bagnat

Clathrin-coated endocytic tubules mediate rapid and selective protein absorption by lysosome-rich enterocytes

This study identifies clathrin-coated endocytic tubules in lysosome-rich enterocytes that enable rapid and selective protein uptake in zebrafish and mice.

A self-limiting mechanotransduction feedback loop ensures robust organ formation

The paper shows Yap mechanotransduction creates a self-limiting feedback loop for zebrafish semicircular canal formation, integrating mechanical forces and transcriptional responses to ensure robust development.

Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish

This study shows that zebrafish adapt to protein malnutrition through genome-wide transcriptional changes that enhance intestinal function and survival.

Hydrostatic pressure shapes and canalizes semicircular canal morphology to ensure vestibular function

The paper shows hydrostatic pressure from the inflating otic vesicle shapes zebrafish semicircular canals, driving pillars toward a common geometry and ensuring vestibular function.

Tissue-wide Erk oscillations set the pace of zebrafish notochord segmentation

This study identifies tissue-wide Erk oscillations that time zebrafish notochord segmentation and reveals the mechanism controlling its onset and tunability.

Unsaturated lipids as key control points for caveola formation and disassembly

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

High-speed 4D fluorescence light field tomography of whole freely moving organisms

This paper introduces ReFLeCT, a high-speed volumetric fluorescence imaging technique that captures 4D videos of freely moving zebrafish and Drosophila larvae with high-resolution 3D reconstruction.

Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

The paper characterizes the fetal development and function of the rete ovarii, identifying it as a secretory structure with potential roles in ovarian function and homeostasis.

Phased ERK-responsiveness and developmental robustness regulate teleost skin morphogenesis

The paper studies ERK signaling dynamics in zebrafish periderm during axial elongation, finding stage-dependent responsiveness and developmental robustness.

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

This study shows that zebrafish gut microbiome influences protein absorption by altering lysosome-rich enterocytes' expression of digestion machinery and microbial interactions.

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2

The paper identifies Plexin-D1 as a mechanosensor that regulates Dorsal Aorta caliber through KLF2-mediated endothelial cell enlargement.

Axial segmentation by iterative mechanical signaling

This study shows that mechanical signaling between myosepta and the notochord sheath coordinates spinal segmentation in zebrafish.

Knock-in tagging in zebrafish facilitated by insertion into non-coding regions

The paper describes a method to generate endogenously tagged zebrafish knock-in lines by inserting fluorescent markers into non-coding regions of genes.

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

This study shows high fat diet causes EEC silencing, a nutrient-insensitive state linked to ER stress, which is microbiota-dependent in zebrafish.