Manvendra Kumar Singh

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

The paper identifies heritable telomere variant sequences that determine allele-specific telomere length and shows their role in telomere maintenance and inheritance.

Antagonistic Regulation of LINE-1/Alu Elements and Their Repressor APOBEC3B in Cellular Senescence

This study identifies APOBEC3B depletion as a driver of L1 element derepression and increased DNA damage in senescent cells through high-throughput sequencing and Ribo-seq analysis.

YAP/TAZ activation in fibroblasts coordinates fibrotic remodeling, fibroinflammation, and epithelial dysfunction in pulmonary fibrosis

This study shows YAP/TAZ activation in fibroblasts drives fibrosis, fibroinflammation, and epithelial dysfunction in pulmonary fibrosis, with potential therapeutic targeting.

YAP/TAZ are Crucial Regulator of Macrophage-mediated Pulmonary Inflammation and Fibrosis after Bleomycin-induced Injury

This study shows YAP/TAZ regulate macrophage behavior in pulmonary fibrosis, affecting inflammation, fibrosis, and tissue regeneration in mice.

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2

The paper identifies Plexin-D1 as a mechanosensor that regulates Dorsal Aorta caliber through KLF2-mediated endothelial cell enlargement.

PiggyBac Transposable Element-derived 1 controls Neuronal Progenitor Identity, Stress Sensing and mammal-specific paraspeckles

The paper investigates PGBD1's role in neuronal progenitor identity, stress sensing, and mammal-specific paraspeckles, showing its dual function in DNA binding and protein interaction.