Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia.
Deepali Vasoya, Lois Keavey, Clara Levit, Tijs Watzeels, Samuel Heron, Justyna Cholewa-Waclaw, Owen Dando, Renzo Mancuso, Kathryn R. Bowles
The paper compares two iPSC-microglia protocols to assess how the MAPT-S305N mutation affects microglial function and neuronal health in a frontotemporal dementia model.
bioRxiv · Jul 4, 2026 · PreprintNeuroscience