Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, Joshua D. Samuels, Nicole E. Eassa, Chelsie N. Poffenberger, Michael L. Lehmann, Samuel J. Listwak, Ferenc Livák, Abdel G. Elkahloun, Menna Ruth Clatworthy, Edward Thomas Bullmore, Miles A. Herkenham
Chronic social defeat stress increases meningeal neutrophils via type I interferon signaling from skull bone marrow, contributing to behavioral issues, and blocking this pathway reduces neutrophil trafficking and improves behavior.
bioRxiv · Aug 30, 2024 · PreprintNeuroscience