Menna Ruth Clatworthy

An Integrated Atlas of the Human Kidney Spanning Health and Diseases

The paper integrates multiple single-cell and single-nucleus RNA-sequencing datasets to create a comprehensive Human Kidney Cell Atlas, identifying cell types, states, and disease-associated populations.

Multi-scale modeling of human tissues from spatial transcriptomics with TERRA

TERRA is a foundation model for spatial transcriptomics that predicts tissue behavior under perturbation and identifies multi-scale biological insights across tissues.

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

An integrated single cell and spatial omics atlas of human prenatal development

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

Multifaceted B-cell response to transient HIV viraemia in elite controllers

This study investigates the B-cell response to transient HIV viraemia in elite controllers, revealing TLM heterogeneity and the role of innate-like B cells.

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

Mapping and reprogramming human tissue microenvironments with MintFlow

MintFlow is a generative AI algorithm that predicts how tissue perturbations reprogram cell states in disease, revealing novel cell populations and therapeutic targets in three human conditions.

Myeloid-Driven Inflammation in Prodromal Parkinson's Disease

The paper identifies increased myeloid-driven inflammation in the CNS of prodromal Parkinson's Disease patients, linking gut and CNS immune responses through shared T cell clones.

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling

Chronic social defeat stress increases meningeal neutrophils via type I interferon signaling from skull bone marrow, contributing to behavioral issues, and blocking this pathway reduces neutrophil trafficking and improves behavior.

Identification of a core transcriptional program driving the human renalmesenchymal-to-epithelial transition

The paper identifies a core transcriptional program driving the human renal mesenchymal-to-epithelial transition using human renal organoids and multi-ome profiling.

Predicting the impact of sequence motifs on gene regulation using single-cell data

The paper uses a convolutional neural network to identify regulatory motifs and their cell type-specific importance from single-cell data, explaining 29% of gene expression variance in mouse tissues.

Spatially resolved multiomics of human cardiac niches

This paper uses spatial transcriptomics and single-cell data to identify cellular niches in the human heart, revealing new insights into cardiac function and potential drug targets.

Multi-regional characterisation of renal cell carcinoma and microenvironment at single cell resolution

A multi-regional single-cell study of kidney tumours reveals clonotypic heterogeneity, immune cell exhaustion, and potential therapeutic targets through transcriptomic and exomic analysis.

Lung, spleen and oesophagus tissue remains stable for scRNAseq in cold preservation

This study evaluates the impact of cold storage on scRNAseq data quality for lung, spleen, and oesophagus tissues, finding minimal effects within 24 hours but increased stress markers at 72 hours.