Na+/H+ Exchanger Isoform 1 Regulates Apoptosis Susceptibility in Pulmonary Arterial Smooth Muscle from the Sugen/Hypoxia model of Pulmonary Hypertension
Manuella Ribas Andrade, Xin Yun, Michael P. Croglio, Shannon E. Niedermeyer, Haiyang Jiang, Nicolas M. Philip, Samuel Murray, Micheal Munson, Karthik S. Suresh, Mahendra Damarla, John Huetsch, Larissa A. Shimoda
This study shows NHE1 promotes apoptosis resistance in PASMCs from PH models through p38 suppression, independent of ion transport or ezrin-binding.
bioRxiv · Nov 6, 2025 · PreprintPhysiology