Youth-associated protein TIMP2 alters microglial state and function in the context of aging
Brittany M. Hemmer, Ana Catarina Ferreira, Sarah M. Philippi, Samuele F Petridis, Annie Phan, Joseph M. Castellano
This study shows that TIMP2 mitigates age-related microglial dysfunction by reducing activation and enhancing phagocytosis in aged mice.
bioRxiv · May 20, 2025 · PreprintNeuroscience