Author

Sarah M. Philippi

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4206-7575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph M. CastellanoiD· 3 shared Ana Catarina FerreiraiD· 2 shared Brittany M. HemmeriD· 2 shared Alejandro Borja Grau-PeralesiD· 1 shared Annie PhaniD· 1 shared Hanxiao LiuiD· 1 shared Jacob L. Rosenstadt· 1 shared Jeffrey D. ZhuiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Joseph M. CastellanoORCID

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3 papers

Recent·Most cited

Youth-associated protein TIMP2 alters microglial state and function in the context of aging

Brittany M. Hemmer, Ana Catarina Ferreira, Sarah M. Philippi, Samuele F Petridis, Annie Phan, Joseph M. Castellano

This study shows that TIMP2 mitigates age-related microglial dysfunction by reducing activation and enhancing phagocytosis in aged mice.

bioRxiv · May 20, 2025 · PreprintNeuroscience

Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

Ana Catarina Ferreira, Brittany M. Hemmer, Sarah M. Philippi, Alejandro Borja Grau-Perales, Jacob L. Rosenstadt, Hanxiao Liu, Jeffrey D. Zhu, Tatyana Kareva, Tim Ahfeldt, Merina Varghese, Patrick R. Hof, Joseph M. Castellano

This study shows that neuronal TIMP2 regulates hippocampus-dependent memory by controlling extracellular matrix accumulation and adult neurogenesis.

Molecular Psychiatry · Sep 1, 2023Peer-reviewedNeuroscience

APOE genotype or presence of brain amyloid alters the plasma proteome in cognitively normal, elderly subjects

Sarah M. Philippi, Kailash BP, Towfique Raj, Joseph M. Castellano

The paper examines how APOE genotype and brain amyloid presence affect plasma proteome composition in cognitively normal elderly individuals, identifying associated molecular pathways.

bioRxiv · Dec 28, 2022 · PreprintNeuroscience