Joseph M. Castellano

This study shows that TIMP2 mitigates age-related microglial dysfunction by reducing activation and enhancing phagocytosis in aged mice.

The paper identifies Meibomian gland stem cell populations and mechanisms of aging using mouse models and finds Hh signaling regulates stem cell proliferation, with decreased Hh and EGF signaling in aged glands.

This study uses Mendelian Randomization to identify causal relationships between circulating biomarkers and diseases, finding novel associations between glucose and cystatin C with bipolar disorder.

This study shows that neuronal TIMP2 regulates hippocampus-dependent memory by controlling extracellular matrix accumulation and adult neurogenesis.

The paper examines how APOE genotype and brain amyloid presence affect plasma proteome composition in cognitively normal elderly individuals, identifying associated molecular pathways.