The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
Min Zhang, Chengqi C. Q. Wang, Jenna Oberstaller, Phaedra J. Thomas, Thomas D. Otto, Debora R. Casandra, Sandhya Boyapalle, Swamy Rakesh Adapa, Shulin Xu, Katrina A. Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams
The paper identifies genes in Plasmodium falciparum that enable survival at febrile temperatures and links these to artemisinin resistance through apicoplast-related pathways.
Nature Communications · Jul 27, 2021Peer-reviewedGenomics