This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.

Science Advances · Dec 18, 2024Peer-reviewedBiochemistry

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

Chengqi C. Q. Wang, Yibo Dong, Chang Li, Jenna Oberstaller, Min Zhang, Justin Gibbons, Camilla Valente Pires, Mianli Xiao, Lei Zhu, Rays H. Y. Jiang, Kami Kim, Jun Miao, Thomas D. Otto, Liwang Cui, John H. Adams, Xiaoming Liu

MalariaSED predicts chromatin profiles in malaria parasites and identifies noncoding variants linked to invasion and drug resistance.

Genome biology · Oct 16, 2023Peer-reviewedBioinformatics

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

Min Zhang, Chengqi C. Q. Wang, Jenna Oberstaller, Phaedra J. Thomas, Thomas D. Otto, Debora R. Casandra, Sandhya Boyapalle, Swamy Rakesh Adapa, Shulin Xu, Katrina A. Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams

The paper identifies genes in Plasmodium falciparum that enable survival at febrile temperatures and links these to artemisinin resistance through apicoplast-related pathways.

Nature Communications · Jul 27, 2021Peer-reviewedGenomics