Cell BiologybioRxivPreprint
Development of a PROTAC Targeting Chk1
Sandipan Roy Chowdhury, Patrick Chuong, Victoria E. Mgbemena, Alexander V. Statsyuk
This paper designs and synthesizes Chk1 degraders using a promiscuous kinase binder and thalidomide, showing concentration-dependent reduction of Chk1 in A375 cells.
DOI 10.1101/2023.12.30.573733