The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S. Schiergens, Georg Herrler, Nai‐Huei Wu, Andreas Nitsche, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann
The paper shows that 2019-nCoV uses ACE2 and TMPRSS2 for cell entry, identifies TMPRSS2 as a therapeutic target, and demonstrates neutralization by SARS patient serum.
Cell · Mar 8, 2020Peer-reviewedMolecular Biology