Christian Drosten

This study evaluates a human DPP4 transgenic hamster model for MERS-CoV infection and transmission, showing efficient viral replication and similar clinical outcomes with two MERS-CoV strains.

This study recovers an ancient Bandavirus genome from a 1919 bat sample and identifies its modern presence in European bats, showing its ability to block interferon induction.

This study uses serosurveys to detect RNA virus-reactive antibodies in bats and rodents, revealing high seroprevalence of flavi- and paramyxoviruses in African Pteropodidae.

The paper compares MERS-CoV variants from Arabian and African camels, showing Arabian viruses are more resistant to inhibition by human soluble DPP4 due to the Q1020R mutation in the spike protein.

The study analyzes MERS-CoV genetic diversity in Saudi Arabian dromedary camels and humans, identifying new variants with unique Spike protein polymorphisms.

This study identifies an ACE2-independent pathway for sarbecovirus entry in human cells, mediated by TMPRSS2-related proteases and linked to reduced antibody neutralization.

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

The paper analyzes genome sequences from the 2022 European monkeypox outbreak to identify genetic variability, including gene duplication and deletion, and their potential role in viral adaptation.

The paper introduces iKiP-DB, a database that predicts kinase activity from phosphoproteomic data, showing its effectiveness in analyzing both well-known and understudied kinases.

This paper engineers tetrahedral antibodies with a non-planar architecture to overcome steric constraints in multispecific therapy, showing improved stability and in vivo efficacy in non-human primates.

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.

The paper investigates SARS-CoV-2 entry into the CNS via the olfactory mucosa in COVID-19 patients and demonstrates neurotropism and cerebral thromboembolism.

The paper shows that 2019-nCoV uses ACE2 and TMPRSS2 for cell entry, identifies TMPRSS2 as a therapeutic target, and demonstrates neutralization by SARS patient serum.