Nadine Krüger

This study evaluates a DNA-adenoviral prime-boost vaccine for RSV in non-human primates, showing reduced viral replication but challenges in multi-centre trials.

This study shows SARS-CoV-2 increases HLA-E expression via spike protein processing, modulating NK cell function by affecting canonical and adaptive NK cells differently during acute infection.

This study identifies an ACE2-independent pathway for sarbecovirus entry in human cells, mediated by TMPRSS2-related proteases and linked to reduced antibody neutralization.

This paper engineers tetrahedral antibodies with a non-planar architecture to overcome steric constraints in multispecific therapy, showing improved stability and in vivo efficacy in non-human primates.

This study shows that the B.1.617.2 variant of SARS-CoV-2 evades antibodies from infection and vaccination, increases lung cell entry, and enhances cell fusion.

The paper shows that SARS-CoV-2 mutations from mink reduce antibody neutralization, suggesting potential risks for human infections.

This study shows camostat mesylate inhibits SARS-CoV-2 by blocking TMPRSS2 and its metabolite GBPA also has antiviral activity, suggesting no resistance through TMPRSS2-related proteases.

The paper shows that 2019-nCoV uses ACE2 and TMPRSS2 for cell entry, identifies TMPRSS2 as a therapeutic target, and demonstrates neutralization by SARS patient serum.